Research Peptides have shown promise with regards to treating a host of health and aging disorders. There use is intended to be experimental in nature, but for at least a decade, bodybuilders, fitness competitors, athletes and people looking for longevity have found very positive results using peptides with minimum to no unhealthy side effects!
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FAT LOSS & MUSCLE BUILDING PEPTIDES
CJC-1295 WITH DAC
CJC-1295 with DAC(Drug Affinity Complex) is the long acting version of CJC-1295, users typically take 200-300mcg every 5-7 days, also known as DAC:GRF( drug affinity complex:growth hormone-releasing factor) in multiple studies CJC-1295 has been shown to increase serum plasma levels of IGF-1(Insulin Like Growth Factor 1) by 1.5 to 3 fold for 9-11 days, and plasma serum GH (Growth Hormone) from 2 to10 fold for 6 days and longer. The benefit of the long-acting CJC-1295 is that for people who are averse to injections must do it once every 5 or so days.
CJC-1295 without DAC
CJC-1295 is a synthetic analog GHRH (Growth Hormone Releasing Hormone) and sometimes known as GRF (Growth Hormone Releasing Factor) which fall under class of peptides know as GHS (Growth Hormone Secretagogues. This particular variant of CJC-1295 is the non DAC version which would need to be dosed several times a day, this in turn would stimulate Growth Hormone and IGF-1 (Insulin Like Growth Factor 1) pulses shortly after administration. Ideal administration time are first thing in the morning upon awakening, 30 minutes before you eat, post workout is also ideal, as both of these times are associated with low carbohydrate environments, which subsequently can be high Growth Hormone environments.CJC-1295 is a synthetic analog GHRH (Growth Hormone Releasing Hormone) and sometimes known as GRF (Growth Hormone Releasing Factor) which fall under class of peptides know as GHS (Growth Hormone Secretagogues. This particular variant of CJC-1295 is the non DAC version which would need to be dosed several times a day, this in turn would stimulate Growth Hormone and IGF-1 (Insulin Like Growth Factor 1) pulses shortly after administration. Ideal administration time are first thing in the morning upon awakening, 30 minutes before you eat, post workout is also ideal, as both of these times are associated with low carbohydrate environments, which subsequently can be high Growth Hormone environments.
GHRP-2 also known as Pralmorelin is a GHSR (Growth Hormone Secretagogue Rceptor) agonist, as well as a Ghrelin agonist, Ghrelin increases appetite and Growth Hormone secretion, so GHRP-2 has the ability to increase serum Growth Hormone levels as well as improve appetite.
GHRP-6 is also a Ghrelin agonist and GH secretagogue, though it’s effect on hunger are more pronounced than GHRP-2, so if appetite is something a person struggles with, this will help immensely. Widely used by bodybuilders on bulking cycle, it also has the added benefit of alleviating the bloated feeling of high calorie bulking diets.GHRP-6 is a Ghrelin agonist and GH secretagogue, though it’s effect on hunger are more pronounced than GHRP-2, so if appetite is something a person struggles with, this will help immensely. Widely used by bodybuilders on bulking cycle, it also has the added benefit of alleviating the bloated feeling of high calorie bulking diets.
HGH Fragment 176-191
It has been shown to stimulate lipolysis, slow the process of lipogenesis, and exhibit antibiotic tendencies that are consistent with antigen binders.
How Fragment 176-191 Functions
According to a scientific study that has been conducted on animal test subjects, Fragment 176-191 functions by essentially mimicking the secretions that essentially control fat metabolism. However, the peptide has been shown to do so without creating the adverse effects that may otherwise happen in relation to blood sugar or cell proliferation. Because it can seize regulatory control of fat metabolism, it has been shown that it promotes the breaking down of body fat, promotes energy expulsion, boosts fat oxidation, and even elevates muscle mass.
Why Fragment 176-191 Functions
Scientific study based on animal test subjects has determined that Fragment 176-191 can function in this manner because it has an interactive relationship with the cytoplasm and the endoplasmic reticulum membrane that can be found within each cellular unit in an animal test subject. Fragment 176-191 works in conjunction with these two components to stimulate the ubiquitin-protein hydrolase involved in processing ubiquitinated proteins and ubiquitin antecedents. This enzyme will, in turn mark the peptide bond at the glycene C-terminal of ubiquitin. Also, the peptide may bond to an unfettered monoubiquitin in order to inhibit the degradation of lysosomes; the cell organelle that is chiefly responsible for breaking down waste materials and other cellular debris.
What These Processes Mean
A Scientific study that has been based on animal test subjects has shown that Fragment 176-191 can be hypothetically linked to a host of different benefits.
The first hypothetical benefit that has been linked relates to the process of lipolysis; that is, the breakdown of adipose tissue, also known as body fat.
According to a scientific study that has been built on animal test subjects, it has been determined that the presence of the peptide can allow for a rate of lipolysis to occur 12.5 times stronger than the rate when the peptide is not present.
This then leads to a significantly more efficient rate of fat burning.
Furthermore, it was determined that Fragment 176-191’s elevated process of lipolysis was not associated with any negative side effects, which sets the peptide apart from other peptides that have been shown to function in a similar manner.
Another benefit that has been theorized relates to Fragment 176-191’s association with brain membranes. Specifically, a scientific study based on animal test subjects has derived the notion that the presence of the peptide can play a key role in the treatment or even the prevention of Parkinson’s disease and Alzheimer’s disease. The reason for this concept is due to the fact that the neuroendocrine systems of those that suffer from Parkinson’s or Alzheimer’s have been shown to have down-regulated versions of Fragment 176-191. Thus far, it has been thought that the presence of Fragment 176-191 may act to offset the toxicity of the protein malfunctions that have been shown to promote the onset of Alzheimer’s. Furthermore, it has been hypothesized that the presence of the peptide may be able to prevent the type of basal lesion that have been shown to contribute to the onset of Parkinson’s disease.
Insulin’s Reaction to Fragment 176-191
Scientific study that has been conducted on animal test subjects has also determined that there may be a link in the way in which Fragment 176-191 functions and the pancreas secreted peptide insulin. These particular studies have indicated that the presence of the peptide have increased the levels of blood glucose in animal test subjects over a short period of time, and it allowed an animal test subject to experience a longer lasting increase of insulin levels in their plasma. These particular findings allowed researchers to show how amino acids work together in order to improve insulin travel regulation as a means to achieve a certain level of homeostasis. What’s more, these studies on insulin demonstrated that a peptide-like Fragment 176-191, which is determined to be bioactive in nature, can remain fully operational with a minimum of the proper informational sequence.
IGF-1 LR3, Insulin like Growth Factor 1, is a 70 Amino Acid Hormone whic is a by product of Growth Hormone metabolism, and is responsible for most of Growth Hormone’s anabolic and fat loss (Lipolytic) properties, during intense training it can truncate into IGF-1 Ec, also known as MGF or Mechano Growth Factor. The IGF’s are instrumental in Myoblast (a type of stem cell) proliferation and differentiation, resulting in increases in muscle mass. Another advantageous effect of increased plasma levels of Growth Hormone and IGF-1 inhibits uptake of Glucose by peripheral tissues, which increase muscle lipid metabolism and thus increasing the rate of fat loss!
Ipamorelin is a pentapeptide that stimulates the GHS (Ghrelin/Growth Hormone Secretagogue Receptor. Ipamorelin will increase plasma serum Growth Hormone levels, but unlike with some other peptides which have similar action, will not increase ACTH (Adrenocorticotropic Hormone) or Cortisol. The other benefit coming from anecdotal evidence is that it doesn’t lower blood sugar as much when you start cycling it or increase appetite to the degree that GHRP-2 and GHRP-6 will.
Hexarelin has been a somewhat overlooked peptide, and it shouldn't be be! The GH pulse is larger than from any other peptide, and is amplified when taken in conjunction with CJC-1295, it has also been shown to increase bone mineral density, as well as aid in fat loss, as all peptides that increase serum Growth Hormone and IGF-1 would do. Notably it has been shown to aid in heart repair and to positively aid repair with regards pressure in the left ventricle.